Dr. Paloma Tejero
Aesthetic Physician, President of GEMEON, Director of the Master of Aesthetic Medicine at the University of Alcalá and honorary member of SEME.
The microneedling (MN) technique is based on the use of minimally invasive micron-sized devices that break the outermost layer of the skin, the stratum corneum (SC), creating transient aqueous pores in the skin that facilitate the transport of therapeutic molecules to the epi-dermis.
We now know that in addition to being vehicles for delivering cosmeceutical molecules through the skin, the technique per se produces a biological stimulation that induces elastin and collagen expression and deposition, improves vascularization of the treated area and activates platelet growth factors PDFG and growth factors IGF1.
One of the most demanded treatments in the office are skin dyschromias and photoaging treatment. It is known that increased oxidative stress caused by ultraviolet B radiation (UV-B) induces melanogenesis and activates metalloproteinases (MMPs), which degrade collagen and elastin fibers, leading to a decrease in skin elasticity. Many treatment modalities have been developed peeling, laser… However, in recent years resistant forms of melasma have emerged that do not respond to the usual first line treatment options, which makes it necessary to explore alternatives.
The use of tranexamic acid is currently one of the therapeutic alternatives proposed for these patients, and we are beginning to have publications that endorse its use by different routes, including the route of application by microneedling.
There are also references to other studies that support the use of other antioxidant agents such as vitamin C and niacinamide, through the use of microneedling, for use as treatments for photoaging or skin pigmentation.
Inbiowhite is intended to inhibit melanogenesis and to unify and lighten skin tone. The main active ingredients of this lyophilized product are :
> HYALURONIC ACID
> ORGANIC SILICON
All of them are well known and have been evaluated, so we decided to incorporate them into our therapies.
A total of 28 treatments have been performed on 12 patients, (2-3 treatments with an interval of three weeks between sessions). 11 women and one man between the ages of 35 and 60 years, and phototypes 2-3. All patients have shown an improvement in terms of lightening of skin tone and decrease in the intensity of melasma. Lentigines are not modified.
In all patients, the general condition of the skin was improved, not only because of the lightening and greater luminosity, but also because of greater firmness and attenuation of fine lines. The treatment is very well tolerated by the patients, only one erythema has been observed, lasting 24-48 hours and some very small, almost imperceptible scabs that disappear after 48 hours.
We can affirm that, despite the number of patients, Inbiowhite is one of the most accepted and promising treatments, in line with the scientific literature consulted.