At the forefront of aesthetic medicine, the approach has evolved from superficial correction to regenerative treatment. The new luxury in aesthetics is healthy, functional, and long-lasting skin. Inbiotec Amber aligns with this philosophy as the first “skin builder,” a medical injectable that rehabilitates the skin from its physiology, targeting both chrono- and photoaging. It is a medical device that contains 1.1% (11 mg/ml) high molecular weight hyaluronic acid (HA) (approximately 2 MDa) and 1.6% (16.9 mg/ml) succinic acid (SA).
The concept of cellular “rehabilitation” is based on the synergy of its two main components, both biocompatible and naturally present in the body. Let’s take a closer look.
Skinbuilding Action: the power of Hyaluronic Acid and Succinic Acid
The skin builder concept of Inbiotec Amber lies in the combination of two biocompatible actives we’ve already introduced. This synergy addresses the three primary causes of skin aging:
- Dehydration and volume loss: Skin aging is characterized by the reduction of HA in the skin, which leads to loss of volume, hydration, elasticity, and firmness. The HA in Amber is high molecular weight (HMW-HA) and non-crosslinked, which means it does not act as a volumizing filler, but as a deep hydrator and structural support in the dermis that attracts water.
- Metabolic slowdown: Aging involves a deceleration of cellular metabolic processes, resulting in a slower production of collagen and elastin, which are responsible for the skin’s structure.
- Oxidative stress (accumulation of free radicals): The build-up of free radicals (pollution, UV radiation, smoking, etc.) and the phenomenon of low-grade chronic inflammation, known as “inflammaging”, are key drivers of premature aging and deterioration of skin quality.
Energy recovery: Succinic Acid as a mitochondrial stimulant
As mentioned, chronological aging is marked by a slowdown in cellular metabolic processes. Succinic acid, as an essential metabolite, directly addresses this cause.
Succinate is a fundamental intermediate in the Krebs Cycle (or tricarboxylic acid cycle, TCA), which takes place in the mitochondria and is crucial for cellular respiration and energy production.
The stimulation of succinic acid helps reverse this metabolic slowdown and boost cellular metabolic processes. This mitochondrial activation leads to increased production of Adenosine Triphosphate (ATP) and NADH. This greater energy (ATP) translates into enhanced cellular repair and improved cell function, increasing skin elasticity, firmness, and smoothness.
Dermal and structural regeneration
The metabolic reactivation induced by succinate has a direct and powerful effect on fibroblasts, the cells responsible for synthesizing the structural components of the dermis. In vitro studies show that HA and sodium succinate act synergistically to stimulate these cells with a greater effect than HA alone. The number of fibroblasts can increase by up to 300% with the combination, compared to 200% with HA as a single component.
This increase in fibroblast activity leads to accelerated synthesis of collagen and elastin. Furthermore, treatment with sodium succinate (alone or combined with HA) showed a significant increase in the expression of key growth factors for tissue repair.
Controlling Inflammaging
Aging is associated with inflammaging, a low-grade chronic inflammation that accelerates tissue degradation. Succinate provides a strong anti-inflammatory effect that helps reduce the release of inflammatory cytokines.
Recent research indicates that the succinate/SUCNR1 system is involved in the formation of the reparative (anti-inflammatory M2) macrophage phenotype. Activation of SUCNR1 in immune system cells (such as macrophages) can modulate the transcription of immune function genes, promoting an anti-inflammatory program and facilitating tissue repair.
When shifting to the “repair mode (M2),” these macrophages release growth factors (such as VEGF for angiogenesis and TGFβ1 for fibroblast proliferation) and help block inflammaging.
Clearly visible clinical results
Thanks to its innovative combination of hyaluronic acid and succinic acid, Inbiotec Amber offers genuine cellular skin rehabilitation, acting simultaneously on four key factors of aging: dehydration, metabolic slowdown, oxidative stress, and chronic inflammation.
The visible clinical result is more hydrated, elastic, and firm skin, with an improvement that goes beyond the surface. This “skin builder” approach positions Inbiotec Amber as a comprehensive solution for skin rejuvenation and dermal healing.
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